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Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins

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Recent studies have shown increasing cases involving gastrointestinal problems linked to glucagon-like peptide-1 (GLP-1) receptor agonists.