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Susan Mollan, a consultant neuro-ophthalmologist at the University Hospitals Birmingham in the United Kingdom, wrote in an email that past trials in people with diabetes have shown that when a patients blood sugar control is tightened, they may have a paradoxical worsening of their diabetic retinopathy (temporarily), so its plausible that the GLP-1 drugs, which also help control blood sugar, could have a paradoxical biological effect. Mollan wrote an editorial that was published alongside the new study

Combined Risk When NSAIDs and semaglutide are used together, they can have a compounding effect: NSAIDs may reduce blood flow to the kidneys

These findings highlight a distinct bioenergetic profile in cells under obese versus lean conditions

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