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Acknowledgements This study was performed with the support of the National Natural Science Foundation of China (82002339, 81820108020), Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System (BJ1-9000-22-4002)

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To gain deeper insights into the impact of the conjugate on both the brainstem and the mesolimbic reward system, we conducted complementary transcriptomics analyses (Extended Data Fig

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Recent studies have recognized the dual anti-inflammatory and glycemic control properties of teneligliptin, which imply that it may have additional benefits aside from glucose control [23]

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Additionally, a large meta-analysis of 94,885 patients with Medicare demonstrated a 37% reduction in mortality 4 years after bariatric surgery with benefits evident in males and females as well as individuals with and without a pre-surgical diagnosis of diabetes [22]

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