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The strong albumin binding and low IR affinity (slow initiation of insulin action) ensure that despite the large weekly dose, there is no immediate large glucose-lowering effect
It has been shown that patients with major depressive disorder have systemic and localized disorders of glucose metabolism throughout the course of the disease, disrupting various processes such as glucose uptake, glycoprotein transport, glycolysis, the tricarboxylic acid cycle and oxidative phosphorylation
allow it to reach room temperature before injection to reduce discomfort
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