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Companies in rare diseases, where orphan drug populations are typically too small to generate the Medicare spending levels that trigger negotiation eligibility, face less IRA exposure

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However, these benefits come with challenges

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Second, the analysis included only trials reporting respiratory disease, resulting in an unknown publication bias

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[DOI] [PubMed] [Google Scholar] 56.Polidori D., Iijima H., Goda M., Maruyama N., Inagaki N., Crawford P.A

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