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Data are regularly updating

Several studies show that metformin can increase plasma active GLP-1 level through enhancing GLP-1 secretion from intestinal L cells 21 or inhibiting dipeptidyl peptidase 4-mediated GLP-1 degradation 22,23

This activation triggers a series of events involving a specific network, relayed via t he hypothalamus, resulting in enhanced insulin secretion due to relief from SNS-mediated inhibition, which elicits metabolic improvement in obese mice

Rushing through meals may lead to overeating before these natural appetite-suppressing mechanisms have time to work effectively

10.1002/9780470514757.ch4 96 McEwenB