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To summarize, GLP-1 weight loss drugs work by reducing appetite and consequently decreasing food intake

In the case of GLP-1 two most prominent limitations to drawing specific conclusions about the role of the peptide in regulation of reward are (1) nausea or visceral illness and (2) the non-specific motor disturbance
doi: 10.2147/DDDT.S506957, 101 Montrose-RafizadehC.EganJ

Lixisenatide is potent at the GLP-1R and has a half-life of 34 h [22]

Some patients take 10 to 20 milligrams per daylower than traditional weight-based dosingwith the goal of improving tolerability
