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Safety, Tolerability, and Who Should Consider This Dose A 40-unit maintenance dose is generally well-tolerated in individuals without contraindications, though gastrointestinal side effects (nausea, constipation, diarrhea) remain common, particularly during escalation

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To examine possible associations with morbidity, we compared differences in comorbidities between obesity classes

Metformin has been prescribed off-label for PCOS for decades because it can improve insulin sensitivity, and it remains widely used in clinical practice