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[12] Adverse effects [edit] Preclinical, phase I, and phase II clinical trials indicated that tirzepatide exhibits adverse effects similar to those of other established GLP-1 receptor agonists, such as dulaglutide (sold as Trulicity) and semaglutide (sold as Wegovy, Ozempic, and Rybelsus)

RYBELSUS (semaglutide) tablets, for oral use

Stop the medication and seek care for severe abdominal pain, persistent vomiting, or signs of an allergic reaction

Tirzepatide activates two hormone pathways simultaneously : GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

Long-Term Considerations and Monitoring Regular Monitoring and Check-Ups Regular monitoring is essential when taking Tirzepatide