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The global prevalence of 537 million affected in the age group of 2079 years in 2021 will rise to 783 million in 2045, with the lowest increase in incidence in Europe (13%) and the highest in the African countries south of the Sahara (134%) ( Obesity, defined as a body mass index above 30 kg/m 2 , is also increasingly prevalent worldwide and has become a challenge to the various healthcare systems and societies

Currently, there are several GLP-1 RA medications delivered by injection, which are sold under various brand names, though availability and licensing vary significantly by country (Table 1)

Activation of GLP-1 receptor enhances the chemosensitivity of pancreatic cancer cells

The ECL1 of all activated GLP-1R and GCGR structures consistently adopt -helical conformation bridging extended TM2 and TM3 helices by two short linkers to form extensive interactions with bound agonists

It's like your skin builds a protective wall