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weight loss (Phase 2/3 peak) | ~15% | ~22% | ~24% | | FDA Status | Approved (Wegovy, Ozempic) | Approved (Zepbound, Mounjaro) | Phase 3 (2026) | | Dosing frequency | Weekly | Weekly | Weekly | The additional glucagon receptor agonism is believed to be responsible for retatrutide's greater metabolic rate increase and enhanced fat oxidation compared to dual agonists

The cornerstone of management is dose titration (start low, go slow)

Central obesity can be further classified into visceral and subcutaneous adipose compartments, where visceral obesity is independently associated with cardiovascular disease [55,56,57,58], and may play a key role in mediating cardiometabolic risk in OSA [56, 58,59,60,61,62]

Based on standard FDA review timelines (12 months for priority review), approval is expected in 20262027
