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doi: 10.7326/0003-4819-143-8-200510180-00006

There were discontinuations due to actual or perceived excess weight loss with retatrutide, and dose reductions took place among some participants, Jastreboff said at the press conference

An additive effect on weight loss was also observed in AWARD-10, which studied the GLP-1-RA dulaglutide versus placebo in patients already on SGLT2 inhibitors with 0.9 kg additional weight loss, 98 although SUSTAIN-9 found that semaglutide superimposed on SGLT2 inhibition resulted in 3.8 kg of additional weight loss and a reduction of HbA1c of 1.42

These calculations form the backbone of any reliable tirzepatide measurement conversion for dosing and help precisely measure 2.5 mg of tirzepatide in units or any other specific quantity