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The relationship between diabetes and cognitive impairment involves many aspects, including central insulin signal transduction, nerve fiber damage caused by hyperglycemia, neuritis, oxidative stress, bloodbrain barrier damage, vascular neuropathy, changes in the dopaminergic system, and the effects of advanced glycation end products on metabolism and energy (Figure 1)

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Ive been on multiple biologics over the last 20 years as well. Alicia, 47 years old, diagnosed with RA I am on Ozempic, but I have not seen any change in my RA. Michele, 54 years old, living with RA and diabetes One person mentioned side effects as a reason they stopped GLP-1s

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This will likely make it very difficult going forward for companies relying on increased bariatric surgery volumes for growth, like Teleflex (TFX) or Allurion (ALUR)

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