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Though not recommended explicitly for acute bipolar depression, these agents are often initiated alongside first-line agents as they have a good safety and efficacy record for depressive prophylaxis

442 Preclinical studies have documented the inhibitory effects of GLP-1RAs on the development of AS in animal models

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Both provide stable blood levels when administered consistently and are widely available

For example, while a months supply of Wegovy may cost around $1,349, certain self-pay programs can reduce this to approximately $499 for specific doses