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The sections were then incubated with fluorescence-conjugated secondary antibodies (Alexa Fluor Cy3 and Alexa Fluor 488, 1:500, Beyotime, China)

Serious side effects are rare but may include: Skin issues (rash, blisters, peeling) Vision problems (blurred vision, loss of vision, double vision, eye pain, redness) Seizures Feeling cold, chills, or a low body temperature Cognitive issues (difficulty concentrating, speech problems, confusion, memory problems) Coma (loss of consciousness) Coordination problems Heart-related symptoms (pounding or irregular heartbeat, chest pain, shortness of breath) Altered mental state (inability to respond to surroundings or mood changes) Tiredness Gastrointestinal problems (diarrhea, vomiting, loss of appetite) Kidney issues (intense back or side pain, abnormal urine) Frequent urination, pain while urinating Signs of infection (fever) Bleeding or bruising problems Osteoporosis In general, higher doses of topiramate are associated with an increased risk of adverse reactions

An overview of obesityrelated complications: The epidemiological evidence linking body weight and other markers of obesity to adverse health outcomes

Global Incidence, Prevalence, and Mortality of Type 1 Diabetes in 2021 With Projection to 2040: A Modelling Study

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