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Mechanism of action of GLP-1RAs especially the metabolic reprogramming perspective GLP-1RAs are hormones secreted by intestinal L cells in the ileum and colon following nutrient intake (73)

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45 Among four positions that have been examined for DOTA conjugation, positions 22 and 37 appear to tolerate the bulky substituent with only a moderate decrease in receptor interaction (5- to 10-fold) compared to positions 26 and 34 (50- to 500-fold)