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-arrestin acts as a clathrin adaptor in endocytosis of the 2-adrenergic receptor
Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, et al
Stemming from successful demonstration of their cardiometabolic modulation and reduction of major adverse cardiovascular events in clinical outcome trials, GLP-1 RAs have since been validated as agents with compelling cardiovascular protective properties
10.1016/j.metabol.2013.01.014 113 ThomasC.GioielloA.NoriegaL.StrehleA.OuryJ.RizzoG.et al (2009)
Over the course of the program, many patients achieve up to 15% weight reduction , which is a meaningful milestone for improved health outcomes
