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The best designed study to date is a systematic review of 80 randomized clinical trials involving 107,860 participants, which found no association with GLP-1RA treatment and serious psychiatric adverse effects: major depression, suicide, or psychosis (105)

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However, the blurred line between professional and non-professional institutionswhere significant differences were observed only in engagement metrics, not in core quality scoreswarrants caution (39, 40)

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Mean body weight at randomization (Week 20) was 96.1 kg and mean BMI at randomization (Week 20) was 34.4 kg/m2

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