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d , Molecular dynamics simulation of compound 2 covalently bound to wild-type GLP-1R reveals unwinding of the N-terminal end of helix VI (IKC 6.36b RL, coloured orange) and re-organization of the ionic lock interaction network

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Clinicians must carefully evaluate individual patient risk factors, particularly personal or family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2), before prescribing these agents