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By modulating macrophage polarization towards an M2 subtype, GLP-1RAs can inhibit inflammation occurring in the vessel lumen, an action which would alleviate the progression of atherosclerosis (Figure 2)

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21 Concerns about thyroid malignancy may deter patients from being treated with GLP-1 RAs, yet this association is unproven when compared with known anticipated benefits secondary to weight loss, glycemic control, and reductions in cardiovascular and kidney disease risk

Therefore: 0.25 mL = 2.5 mg