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This can be particularly relevant for drugs with narrow therapeutic windows, such as warfarin (a blood thinner) or digoxin (a heart medication)

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Even after repeated dosing across two weeks, the drug maintained its effectiveness without signs of diminishing returns

In contrast, peripheral antagonism of the GLP-1R by intravenous infusion of exendin(9-39) for several hours did not significantly modulate food intake in human studies (5, 6)