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Besides DM, cardiovascular diseases, and hypertension are important comorbidities that are potentially involved in determining the severity of the infection, disease outcomes, and prognosis [30]

GLP-1 therapies have shown promise in reducing liver fat content, mitigating the progression of NAFLD

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Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: Friend or foe

The clinical evidence establishes unprecedented therapeutic efficacy across established indications, with newer multi-receptor agonists achieving HbA1c reductions exceeding 2.0% in diabetes, weight loss approaching 24% in obesity that rivals bariatric surgery outcomes, and cardiovascular protection demonstrating consistent 1420% MACE reduction with emerging benefits in heart failure with preserved ejection fraction