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Diabetes 2009 , 58 , 975983

Absolute contraindications to GLP-1 receptor agonists include: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pregnancy (for weight management indications) Severe gastrointestinal disease, including gastroparesis Patients should be specifically questioned about these conditions during pre-treatment evaluation
Tirzepatide with B12 only The simplest compounded version

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This means even when one desensitization pathway is blocked, backup systems exist