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Contraindications include personal or family history of medullary thyroid carcinoma and multiple endocrine neoplasia syndrome type 2
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The researchers acknowledged study limitations, including possible outcome misclassification because of the use of diagnostic codes not validated in claims data, potential underrecording of GI adverse events in the claims databases, and not being able to rule out possible residual confounders from certain factors like BMI

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Oral, intravenous, and subcutaneous formulations of factor XI inhibitors are all being studied, in forms including monoclonal antibodies, small molecules, and antisense oligonucleotides
