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Although the potential for GLP-1s to treat SUD and other behavioral health disorders is appealing, its vital to look at the data available on this subject

We know it is harder for individuals with diabetes to lose weight

Identification of the peptide and receptors, however, does not by itself substantiate a functional relevance, but evidence for a physiological role of these receptor populations emerged 13 years later and will be discussed here

Critically, researchers found the CRP reduction was only partially mediated by weight loss

Although not thought to be directly influenced by obesity, lipoprotein (a) is an independent risk factor for cardiovascular disease that is determined by genetics