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Monitoring mental health during the transition to GLP-1 therapy is essential, and any significant mood changes should prompt immediate discussion with a healthcare provider

doi:10.1136/bmj-2025-085304 45.Lillys Foundayo and lower-dose Zepbound helped people maintain weight loss after switching from higher doses of injectable incretin therapy in two late-phase trials

In GLP1R/GIP, behavior-related terms and gastric acid secretion were identified

Therefore, medication selection should match each patients metabolism, health history, goals, and response pattern. Who may qualify for tirzepatide treatment

GLP-1 and GIP help lower appetite and increase insulin release, while glucagon can raise energy use and help the body burn fat
