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Animal models and husbandry Only male mice were studied

In terms of metabolic regulation, GLP-1RAs exert their effects through various pathways, including increasing insulin sensitivity, maintaining glucose homeostasis, promoting weight control, and improving lipid metabolism

When GLP-1 binds to its receptor, it amplifies the insulin signaling pathway, causing increased phosphorylation of insulin receptor substrates and activating the PI3K/Akt pathway, which ultimately results in enhanced glucose uptake, utilization within the liver, and reduced production of glucose (gluconeogenesis)

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