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Beyond endothelial dysfunction, pericyte impairment has been identified as a contributor to diabetic ED [188]

But it is fighting back
2021;23 Suppl 3:529

The acylation does not appear to influence the potency of action at the GIPR, enabling tirzepatide to act as a full agonist at the human GIPR

For constipation , increasing both soluble and insoluble fibre intake is typically beneficial
