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This is the story of how a desert lizards venom traveled from the rocks of Arizona to the pages of the New England Journal of Medicine , and how one scientists refusal to abandon an unfashionable idea changed the face of modern pharmacotherapy

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the former (rat GLP-1R) showed a fivefold reduction in affinity but only 25% of the wild-type response to 100 nM GLP-1, whereas the latter (hGLP-1R) observed a 28-fold reduction in affinity and a 630-fold reduction in potency
