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The main reason for its long half-life is albumin binding
doi: 10.2337/dc20-S009 6 Mata-CasesMFranch-NadalJOrtegaERealJGratacosMVlachoBet al

The most common side effects of semaglutide are gastrointestinal in nature

Animal studies have shown negative effects on fetal development, and there are no adequate studies in pregnant humans

Retatrutide offers a more advanced option because it works with the liver, fat tissue, and insulin pathways together
