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125 This protective mechanism is likely facilitated through the activation of the adenosine 5-monophosphateactivated protein kinase (AMPK) pathway, which plays a crucial role in managing cellular stress and the DNA repair process

CB1 receptors are predominantly distributed in the brain, with particularly high concentrations in the basal ganglia, hippocampus, prefrontal cortex, and cerebellum

LMNs are documents written by healthcare providers justifying the necessity of a medication or treatment

[DOI] [PubMed] [Google Scholar] 898.Pratley R.E., Aroda V.R., Lingvay I., Ludemann J., Andreassen C., Navarria A

The primary anti-inflammatory mechanisms include the inhibition of JAK-STAT and NF-B signaling pathways in keratinocytes, enhanced keratinocyte barrier function through increased expression of tight junction proteins, reduced Th17 polarization that drives psoriatic pathology, and reduced oxidative stress through enhanced expression of antioxidant enzymes [131,139,140]
