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Most studies have been conducted in animal models or small human trials with high risk of bias, and findings often lack replication in larger, well-controlled clinical studies
Both compounds require gradual dose escalation
However, further research is needed to confirm that the improvements in systemic inflammation and joint symptoms observed with these therapies are also tied to improvements in joint inflammation.
Similarly, other cardiovascular outcome trials did not show any difference in the rates of acute pancreatitis between patients receiving GLP-1 receptor agonists vs placebo
Are comfortable with limited regulatory oversight
