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For decades, we've known that excess body weight is a major risk factor for at least 13 types of cancer

40 Insulin receptor is expressed in skeletal muscle, adipocytes, kidneys, brain, blood vessels, heart, liver, pancreatic endocrine cells (such as islet alpha and beta-cells), bone and the GIT

While GIP loses its insulinotropic effect in T2D with chronic hyperglycemia, GLP-1 is still able to stimulate insulin secretion (28, 29)

The FDA and EMA have approved a number of GLP1 receptor agonists, but in this review, we will focus on those compounds that have been investigated preclinically, that is, exenatide, liraglutide, semaglutide and dulaglutide