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43 A similar trend towards a higher risk of unfavourable outcomes was observed in the post hoc analysis of the FIGHT trial
The most common of these include nausea, vomiting, diarrhea, abdominal pain, and constipation

The SURMOUNT-4 trial showed even steeper rebounds with tirzepatide, with participants regaining more than 50% of their weight loss over 52 weeks after stopping

The fed group experienced significantly lower systemic semaglutide exposure after the 10th dose, whereas both the fasting and reference groups achieved therapeutic concentrations [26]

Usually not without speaking to your medical provider
