glp-1 agonist dopamine Frontiers Mechanisms of GLP-1 Receptor Agonist-Induced

Naltrexone blocks the brains reward system, reducing the pleasure response to food and helping control compulsive eating behaviors

Clinical studies show equivalent efficacy and tolerability, with additional advantages of flexible dosing, lower cost, and faster access without insurance delays

3 Originally developed to treat type 2 diabetes and obesity, glucagon-like peptide (GLP)-1 receptor agonists have recently gained attention for their potential role in managing IIH

The beneficial effects of GLP-1 receptor activation on glycemia occur through several mechanisms: GLP-1 stimulates glucose-dependent insulin secretion from pancreatic -cells, suppresses inappropriately elevated glucagon secretion from pancreatic -cells, delays gastric emptying, and induces satiety via a direct action in the central nervous system

In this review, we highlight the drugs in this class, describe their role in glucose homeostasis preservation and the specificities/differences among them, as well as clinical results, safety profiles, and off-label indications within different metabolic diseases