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Although no studies have investigated the expression of GLP-1/GLP-1R in Hoffa's tissue, several studies focused on the role of GLP-1 in white or brown adipose tissue [75,76]

The presence of GLP-1R in hepatocytes, however, remains a subject of debate

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Peak VO 2 improvement was not supported by the pharmacokinetic/pharmacodynamic modelling, indicating no relationship between exposure to albiglutide and peak VO 2

Loss of Skin Elasticity As fat volume reduces, skin elasticity may not keep up, especially in patients over 35