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The logic behind this approach is that the concomitant activation of GLP1 and estrogen receptors may drive additional favorable effects, when compared with the individual activation of these pathways, which are known to conduct, on their own, beneficial metabolic actions on energy and glucose homeostasis 52

Latorre E, Layunta E, Grasa L, et al

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Participants were randomized to receive either semaglutide or placebo, with outcomes assessed using the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS)