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73,74 The anti-fibrotic effects of DPP4 inhibitors such as vildagliptin and sitagliptin have been demonstrated in a mouse model of bleomycin-induced skin fibrosis, characterized by improved dermal texture, reduced hydroxyproline content, and decreased myofibroblast deposition through the inhibition of TGF--induced ERK signaling

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Reduction in nonfatal MI was noted only with SGLT2i but the effect was modest (10% relative risk reduction)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Mahamat-saleh Y., Aune D., Freisling H., Hardikar S., Jaafar R., Rinaldi S., Gunter M., Dossus L

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