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Men with obesity-related hypogonadism often experience improvements in testosterone levels with sustained weight reduction, though the response varies between individuals and may require weight loss greater than 5-10% in some cases

With a 2.4 mg dose, over 30% of the subjects lost 20% or more of their body weight by week 48 which is better than single drugs [57]

Wu L-T, Ghitza UE, Batch BC, Pencina MJ, Rojas LF, Goldstein BA, et al

While its potent effects are promising, particularly for patients with significant obesity, the more balanced efficacy and tolerability of tirzepatide may be preferred for other patient populations