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Ozempic is a glucagon-like peptide-1 (GLP-1) analog for the treatment type 2 diabetes

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Comparable to therapy with GLP-1RA, a stepwise dose escalation starting with a low starting dose was associated with a lower rate of gastrointestinal side effects and better tolerability of tirzepatide (67)

Activation of PPAR improves insulin sensitivity in the adipose tissue, liver and skeletal muscle 10,11,23