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Butt JH, Petrie MC, Jhund PS, Sattar N, Desai AS, Kber L, et al

Your body develops tolerance as your digestive system adapts to slower gastric motility and your brain adjusts to sustained GLP-1 activation

10.1186/s12933-014-0157-0 54

Changes in HbA1c in participants with pre-existing pre-diabetes between treatment arms, and in participants with pre-existing T2D between treatment arms, was assessed with the inclusion of an interaction term between diabetes status and treatment allocation in the linear regression model for HbA1c and calculated from estimated marginal means

While still effective, these results generally fall short of what Mounjaro achieves