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1,3 A prespecified analysis of the trial (a question the researchers planned to study from the outset) found that only about a third of the reduction in cardiovascular events could be explained by weight loss

It reduces stress-related nerve signals, which helps lower heart rate and relax blood vessels

Losing weight can be challenging, and for some, diet and exercise alone may not be enough

Researchers outside of clinical trial settings rarely access this grade, but it represents the benchmark against which everything else should be measured