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Hepatic steatosis, a further component of the metabolic syndrome, is known to be more common in patients with IBD 110 and GLP-1RAs have previously been shown to be effective for reducing liver fat content, 111 and this represents another potential benefit to GLP-1RA therapy

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For a minority, particularly those with pre-existing imbalances in serotonergic function, the shift could theoretically contribute to anxiety symptoms