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GLP-1R expression changes, usually downregulation (but also upregulation in some cases), have also been reported in various anatomical parts of adipose tissue and in other non-fat tissues during large changes in fat volume and during body weight gain or loss in humans, e.g., in obesity, insulin resistance, after bariatric surgery, etc

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For example, the inner bark extract of Anacardium occidentale significantly reduced hyperglycemia in alloxan-induced diabetic rats [55]