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Specifically, Ex4 blocks the ability of nicotine to activate the mesolimbic dopamine system and cause reward (Egecioglu et al., 2013b), and it also suppresses nicotine intake (Tuesta et al., 2017) in male mice

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As more individuals face health risks associated with excess weight, the demand for GLP-1 receptor agonist, proven to reduce weight, improve glycemic control and lower cardiometabolic risk, is expected to rise substantially, thereby driving the growth of the GLP-1 receptor agonist market

GLP-1R on arcuate nucleus neurons expressing POMC/CART can mediate Liraglutide-induced weight loss (Secher et al., 2014)

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