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Abstract Physicians and patients have long been aware of skin lesions at the sites of insulin injections, referred to as lipodystrophy that can present as lipoatrophy (LA) or lipohypertrophy (LH)

doi: 10.1152/physrev.00034.2006 37 MarsoSPDanielsGHBrown-FrandsenKKristensenPMannJFNauckMAet al

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Willard FS, Douros JD, Gabe MB et al (2020) Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

In addition cortisols lipolytic activity with increase in circulating free fatty acids contributes to insulin resistance ( Table 1 )
