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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to provide benefits regarding weight loss and improvements in cardiometabolic risk factors in individuals with obesity [14]

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Clinically, as a prescriber of a variety of the GLP-1 medications, I can say that many patients on these medications have prior diagnoses of anxiety and/or depression, and a vast majority of patients who have seen positive results from these medications would report improvement in their depression and anxiety symptoms

Other causes of death included cardiovascular events (4 cases, distributed across the tirzepatide groups) and indeterminate causes (2 cases, 1 each in the 5 mg and 10 mg tirzepatide groups)

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