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Description
The pain characteristically worsens after eating and is not relieved by over-the-counter medications
Semaglutide trials (STEP program) reported nausea in approximately 25-35% of participants at therapeutic doses
At the N-terminus, the His7 of Semaglutide forms a direct hydrogen bond with the side chain of Gln234 and a water mediated hydrogen bond with Tyr241 of the receptor
Large meals become uncomfortable when gastric emptying is slowed
Original publication: Robert M
