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The powdered allulose below contains finely ground allulose in pure form or combined with a pinch of monk fruit and stevia extract

Overall, while some data hint at potential neuroprotective effects, current imaging results are inconclusive and highlight the need for further studies in larger, early-stage cohorts where imaging biomarkers are more sensitive to change

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Mechanistically, GLP-1R activation appears to downregulate TNF- production via 1-adrenergic, -opioid, and -opioid receptor pathways (Wong et al., 2024)

Abbreviations BCAAs: Branched-chain amino acids CIs: Confidence intervals DR: Dorsal raphe fMRI: Functional MRI GLP-1RAs: Glucagon-like peptide-1 receptor agonists GWAS: Genome-wide association studies IGF: Insulin-like growth factors IR: Insulin receptor IVW: Inverse-variance weighted LD: Linkage disequilibrium LIRA: Liraglutide LPS: Lipopolysaccharide MDD: Major depressive disorder MHC: Histocompatibility complex MR: Mendelian randomization OCD: Obsessive-compulsive disorder ORs: Odds ratios PGC: Psychiatric genomics consortium RCTs: Randomized controlled trials T2DM: Type 2 diabetes mellitus UKB: UK biobank References U.S