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While cost is a primary consideration for payers, lack of persistence on GLP-1s is another reason for hesitance to reimburse weight loss drugs

Neuroscientist 14 , 182194 (2008)

Rarely, unless combined with insulin or sulfonylureas

GLP-1R agonists can stimulate cell proliferation in vitro by activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) and 5 adenosine monophosphateactivated protein kinase/mechanistic target of rapamycin signaling pathways and the inactivation of Forkhead box protein O1 (FOXO1) in pancreatic cell lines as well as in cells in human islets of Langerhans

Collectively, these studies implicate a rationale to use DPP4 inhibitors for vascular repair through stimulation of EPC and neovascularization